Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Grapefruit Meds

Posted by jsarirose on February 13, 2003, at 16:26:55

In reply to Re: Grapefruit Meds » jsarirose, posted by Eddie Sylvano on February 13, 2003, at 16:20:05

> > Isn't grapefruit & grapefruit juice bad to have when you're taking certain drugs? Does anyone know what those drugs are? I can't remember if it pertained to anti-depressants or other meds I take.
> --------------------
>
> This has to do with the fact that something in the juice inhibits the action of certain enzymes in the intestine. If those enzymes were necessary to break down the drug you were taking, the net effect is that more of the drug gets into your bloodstream than would ordinarily (you get more effect from the drug). This should only be an issue if you're taking the drug at roughly (~2 hrs) the same time as the juice. The enzymes affected by grapefruit juice are CYP3A4 and CYP1A2. Some psychiatric drugs that are broken down by these enzymes include:
>
> Buspirone
> Alprazolam
> Triazolam
> Midazolam
> Carbamazepine
> Trazodone
> Nefazodone
> Quetiapine
> Clozapine
> Haloperidol
>
> Your particular drug insert may tell you which CYP450 enzymes are responsible for the drug's breakdown. This is also roughly the same process by which drugs interact with each other, since each drug (just like the grapefruit juice) inhibits or enables their own particular set of enzymes. Some drugs can even inhibit the enzymes responsible for their own metabolism. Craziness.
>
>

Thanks to both messages. I used to be on Klonopin, and now I take Trazadone. I take it at night though, so I guess it would be just fine. I have had grapefruit, but I just remembered I wasn't sure if I was supposed to.

Thanks for the info!

-Jessica


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:jsarirose thread:200153
URL: http://www.dr-bob.org/babble/20030208/msgs/200159.html