Posted by not exactly on February 6, 2003, at 3:50:14
In reply to Mirapex/Selegiline/Parnate » not exactly, posted by jumpy on February 5, 2003, at 17:43:36
> Mirapex is availible in most countries for parkinson's disease ... I am surprised you are not able to find it.
I couldn't get it right after the trial (about 7 years ago) because it hadn't been approved yet. I *was* able to get it a couple of years later. I explained all this in a previous post [http://www.dr-bob.org/babble/20030204/msgs/139600.html].
> Also, if the selegiline patch worked for you ... why not try the standard oral preparation?
I did. For about a year. But it never worked as well. When selegiline is taken orally, the metabolic pathways are somewhat different, and hence the plasma levels of active metabolites end up at different ratios. So the overall effect is not exactly the same. Also, you need to take such a large dose orally that the MAOI diet is mandatory (which I found to be a big disadvantage). Cheese-safe levels of oral selegiline aren't effective as an AD.
> And if you need dopamine, go get your self some parnate at least.
Parnate is near the top of my "to be tried" list, but I'm not looking forward to the MAOI diet restrictions. How can I live without pepperoni pizza? :-(