Posted by Larry Hoover on February 5, 2003, at 20:22:41
In reply to Re: chromium deficiency in atypical depression?, posted by Jack Smith on February 5, 2003, at 20:12:18
> > (70%) CP and zero (0%) PBO patients met responder criteria (p =.02). Other outcomes were consistent with greater effect of CP.
> This looks like promising news except for one thing--what were there "responder criteria"--a 10% improvement???? 20%????
Yes, you've identified the primary limitation in interpreting this small study; it certainly matters what the responder criteria are. However, if the margin of improvement were as slim as you suggest, it would be unlikely that none of the placebo group improved that much by chance or coincidence.
I haven't had time to look into the dose. Does anyone know if 600 mcg is a lot of chromium?