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Re: Some GABAergic drugs you may want to try... temoigneur

Posted by Aadika on December 11, 2002, at 19:47:01

In reply to Re: Some GABAergic drugs you may want to try..., posted by temoigneur on December 11, 2002, at 16:15:18

Hi there, surprising that someone else has been following Riluzole... I've never heard mention of it otherwise. So it's said to have literal anesthetic properties? Like analgesia/sedation? I've heard that it possessed some hypnotic properties, but this is news to me... I suppose at this point I have very high expectations for an anxiolytic medication, as my current meds provide complete relief from my symptoms and no side effects. Right now I'm just interested in trying new drugs more for the science... I mean, if it doesn't work, I know I'll always have my Klonopin. And that thought's exactly what's kept me sane throughout this past year or so of trial after trial of essentially useless medication.

So you had the same problem with Depakote too, huh? What dose were you taking? I was at 1,000mg per day, I believe (it's been a while). I have to wonder if I was just at far too low a dose, seeing as how the drug doesn't have any GABAergic action until the higher doses. But I may just have to continue wondering, as I'd rather not have to deal with all the cognitive dulling I've heard occurs at those levels. Not to mention choking down those ungodly horse pills three times a day! (I already have enough of that with all the vitamin/mineral supplements I take-- I'm a firm believer in 'nutraceuticals'.)

Well, may as well post this. These are some of the drugs I've taken that I can remember offhand (my God, it's actually reached the point that I can't remember them all! lol) and the effect they had on me-- all of them were pushed to the max dose (excluding some of the benzos) before giving up:

Zoloft: no anxiety relief; sedation; sexual dysfunction

Prozac: anxiety MUCH worse; insomnia; brought back symptoms of ADHD that I had as a child

Celexa: minimal anxiety relief; insomnia; sexual dysfunction

Luvox: no anxiety relief; sexual dysfunction

Paxil: adequate anxiety relief; apathy; insomnia; sexual dysfunction; UPON WITHDRAWAL: 'head zaps', which have ceased neither in frequency nor severity in the past two years; status epilepticus

Effexor XR: no anxiety relief; no side effects

Wellbutrin: extreme anxiety, panic, agoraphobia; insomnia

Serzone: no anxiety relief; no side effects

Remeron: no anxiety relief; hypersomnia; lethargy

Desyrel: minimal anxiety relief; hypersomnia

Elavil: somewhat heightened anxiety; hallucinations; lethargy

Anafranil: no anxiety relief; lethargy

Sinequan: moderate anxiety relief; hypersomnia; lethargy

Ludiomil: no anxiety relief; no side effects

Clomipramine: minimal anxiety relief; insomnia; sexual dysfunction

Nardil: no anxiety relief; sexual dysfunction; orthostatic hypotension

Parnate: no anxiety relief; sexual dysfunction; insomnia; slight hyperactivity/euphoria (hypomania?)

Aurorix: no anxiety relief; no side effects

Selegiline: minimal anxiety relief; no side effects

Mirapex: no anxiety relief; slight lift in mood

Ritalin / Concerta: heightened anxiety; muscle tension

Adderall XR: no anxiety relief; no side effects

Dexedrine Spansules: moderate anxiety relief; no side effects

Desoxyn Gradumets: no anxiety relief; mild euphoria; insomnia

Cylert: no anxiety relief; no side effects

Zyprexa: minimal anxiety relief; lethargy

Risperdal: no anxiety relief; no side effects

Seroquel: no anxiety relief; no side effects

Thorazine: minimal anxiety relief; apathy; sexual dysfunction

Mellaril: minimal anxiety relief; apathy

Lithium: no anxiety relief; frequent urination

Neurontin: no anxiety relief; no side effects

Gabitril: no anxiety relief; urinary retention/hesitancy; UPON DR. RAISING DOSE FROM 8mg q.i.d. TO 12mg t.i.d.: brief psychotic episode; status epilepticus preceded by a catatonic state

Trileptal: no anxiety relief; no side effects

Tegretol: no anxiety relief; extreme fatigue

Topamax: no anxiety relief; no side effects

Xanax: complete anxiety relief; strong euphoria; cognitive/coordinational impairment; physical/psychological dependence, rapidly escalating tolerance, and ultimately severe addiction

Ativan: moderate anxiety relief; no side effects

Valium: moderate anxiety relief; dysthymia; irritability

Tranxene: no anxiety relief; no side effects

Librium: moderate anxiety relief; mild euphoria; rapidly-developing tolerance

Paxipam: complete anxiety relief; rapidly-developig tolerance

Serax: moderate anxiety relief; headache

Miltown: no anxiety relief; no side effects

Amytal: no anxiety relief; no side effects

Luminal: no anxiety relief; no side effects

Catapres: minimal anxiety relief; orthostatic hypotension; blurred vision

~~~~~~~~~~~~~~~~

Whew, lol. That excludes several tricyclics, neuroleptics, and I'm sure several others I'm forgetting because I'm so exhausted. And of course it excludes the three meds I'm currently taking, Klonopin, Provigil, and Inderal.

Well, I've got one more post to respond to and then it's definitely off to bed for me. Keep me updated on the Riluzole (and everything else)!

~ Aadika



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poster:Aadika thread:130363
URL: http://www.dr-bob.org/babble/20021210/msgs/131400.html