Posted by Aadika on December 11, 2002, at 19:47:01
In reply to Re: Some GABAergic drugs you may want to try..., posted by temoigneur on December 11, 2002, at 16:15:18
Hi there, surprising that someone else has been following Riluzole... I've never heard mention of it otherwise. So it's said to have literal anesthetic properties? Like analgesia/sedation? I've heard that it possessed some hypnotic properties, but this is news to me... I suppose at this point I have very high expectations for an anxiolytic medication, as my current meds provide complete relief from my symptoms and no side effects. Right now I'm just interested in trying new drugs more for the science... I mean, if it doesn't work, I know I'll always have my Klonopin. And that thought's exactly what's kept me sane throughout this past year or so of trial after trial of essentially useless medication.
So you had the same problem with Depakote too, huh? What dose were you taking? I was at 1,000mg per day, I believe (it's been a while). I have to wonder if I was just at far too low a dose, seeing as how the drug doesn't have any GABAergic action until the higher doses. But I may just have to continue wondering, as I'd rather not have to deal with all the cognitive dulling I've heard occurs at those levels. Not to mention choking down those ungodly horse pills three times a day! (I already have enough of that with all the vitamin/mineral supplements I take-- I'm a firm believer in 'nutraceuticals'.)
Well, may as well post this. These are some of the drugs I've taken that I can remember offhand (my God, it's actually reached the point that I can't remember them all! lol) and the effect they had on me-- all of them were pushed to the max dose (excluding some of the benzos) before giving up:
Zoloft: no anxiety relief; sedation; sexual dysfunction
Prozac: anxiety MUCH worse; insomnia; brought back symptoms of ADHD that I had as a child
Celexa: minimal anxiety relief; insomnia; sexual dysfunction
Luvox: no anxiety relief; sexual dysfunction
Paxil: adequate anxiety relief; apathy; insomnia; sexual dysfunction; UPON WITHDRAWAL: 'head zaps', which have ceased neither in frequency nor severity in the past two years; status epilepticus
Effexor XR: no anxiety relief; no side effects
Wellbutrin: extreme anxiety, panic, agoraphobia; insomnia
Serzone: no anxiety relief; no side effects
Remeron: no anxiety relief; hypersomnia; lethargy
Desyrel: minimal anxiety relief; hypersomnia
Elavil: somewhat heightened anxiety; hallucinations; lethargy
Anafranil: no anxiety relief; lethargy
Sinequan: moderate anxiety relief; hypersomnia; lethargy
Ludiomil: no anxiety relief; no side effects
Clomipramine: minimal anxiety relief; insomnia; sexual dysfunction
Nardil: no anxiety relief; sexual dysfunction; orthostatic hypotension
Parnate: no anxiety relief; sexual dysfunction; insomnia; slight hyperactivity/euphoria (hypomania?)
Aurorix: no anxiety relief; no side effects
Selegiline: minimal anxiety relief; no side effects
Mirapex: no anxiety relief; slight lift in mood
Ritalin / Concerta: heightened anxiety; muscle tension
Adderall XR: no anxiety relief; no side effects
Dexedrine Spansules: moderate anxiety relief; no side effects
Desoxyn Gradumets: no anxiety relief; mild euphoria; insomnia
Cylert: no anxiety relief; no side effects
Zyprexa: minimal anxiety relief; lethargy
Risperdal: no anxiety relief; no side effects
Seroquel: no anxiety relief; no side effects
Thorazine: minimal anxiety relief; apathy; sexual dysfunction
Mellaril: minimal anxiety relief; apathy
Lithium: no anxiety relief; frequent urination
Neurontin: no anxiety relief; no side effects
Gabitril: no anxiety relief; urinary retention/hesitancy; UPON DR. RAISING DOSE FROM 8mg q.i.d. TO 12mg t.i.d.: brief psychotic episode; status epilepticus preceded by a catatonic state
Trileptal: no anxiety relief; no side effects
Tegretol: no anxiety relief; extreme fatigue
Topamax: no anxiety relief; no side effects
Xanax: complete anxiety relief; strong euphoria; cognitive/coordinational impairment; physical/psychological dependence, rapidly escalating tolerance, and ultimately severe addiction
Ativan: moderate anxiety relief; no side effects
Valium: moderate anxiety relief; dysthymia; irritability
Tranxene: no anxiety relief; no side effects
Librium: moderate anxiety relief; mild euphoria; rapidly-developing tolerance
Paxipam: complete anxiety relief; rapidly-developig tolerance
Serax: moderate anxiety relief; headache
Miltown: no anxiety relief; no side effects
Amytal: no anxiety relief; no side effects
Luminal: no anxiety relief; no side effects
Catapres: minimal anxiety relief; orthostatic hypotension; blurred vision
~~~~~~~~~~~~~~~~
Whew, lol. That excludes several tricyclics, neuroleptics, and I'm sure several others I'm forgetting because I'm so exhausted. And of course it excludes the three meds I'm currently taking, Klonopin, Provigil, and Inderal.
Well, I've got one more post to respond to and then it's definitely off to bed for me. Keep me updated on the Riluzole (and everything else)!
~ Aadika
poster:Aadika
thread:130363
URL: http://www.dr-bob.org/babble/20021210/msgs/131400.html