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Re: SERZONE and weight gain Rick

Posted by JohnX2 on December 2, 2002, at 16:09:05

In reply to Re: SERZONE and weight gain JohnX2, posted by Rick on November 27, 2002, at 15:31:50

Just a dart throw, I think the weight gain may
have been related to the noradrenergic alpha-1
receptor blockade.

Serzone has been a weak AD for me, but it is
excellent for my headaches, insomnia, and it
doesn't cause sexual dysfunction.


> As you probably know, Serzone has fairly weak SRI properties, in addition to other mechanisms of action. I would surmise that at a high-end dose (which 600 certainly is), it would have some of the same side effects you'd get with a typical dose of one of the usual SSRI's. I wonder if that could have encouraged weight gain. Along the same lines. I understand that sexual dysfunction, which usually isn't a problem with Serzone, is somewhat more likely at higher-end doses.
> Rick
> > I don't remember the dosage. Probably 450-600 mg.
> > I think it took a while to notice the weight gain, at least a number of weeks as I usually don't look for it but my clothes started to fit
> > tighted. Mostly the medicine made me really drowsy
> > and drunk feeling and greatly increased my appetite. I think the sluggishness may have been an indicator of slower metabolism. I dunno. Plus the pigging out definately was a whammy. When I quit the medicine I stopped the weight gain. The vast majority of people don't gain weight on Serzone.




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