Posted by Michael D on November 18, 2002, at 12:07:21
A possible substitute for Zyprexa and Seroquel:
http://www.namiscc.org/newsletters/February02/aripiprazole.htm
"Stephen M. Stahl, M.D., Ph.D., Professor of Psychiatry at the University of California at San Diego, places aripiprazole in the class of antipsychotics called dopamine system stabilizers (DSSs). Stahl dubs these new therapeutic agents “Goldilocks” because of their ability to strike a balance between too much and too little dopamine. With “just right” result, negative and cognitive symptoms are reduced and motor side effects or prolactin elevation is absent. Previous atypical drugs block dopamine D2 receptors resulting in motor side effects such as pseudo-parkinsonism, and ultimately tardive dyskinesia. "
http://www.narsad.org/pub/sum02med.html
"Aripiprazole (Abilitat)
Aripiprazole is believed to exhibit potent partial agonism of D2 dopamine receptors, and is also associated with partial agonism of 5HT1A serotonin receptors and antagonism of 5HT2A serotonin receptors. This medication's goal is to reduce hyperactive dopamine neurons that mediate psychosis and at the same time enhance underactive dopamine neurons that mediate negative and cognitive symptoms (mesocortical pathway).In a prior clinical study, aripiprazole was found to be as effective as risperidone (Risperdal) in reducing and treating signs and symptoms of schizophrenia. Approximately 10% of patients on aripiprazole or risperidone experienced weight gain of more than 7% from baseline.
"http://www.bms.com/news/press/data/fg_press_release_3271.html
"The companies anticipate that Abilify tablets will be widely available in pharmacies within two weeks. "
Posted by Michael Dewolf
poster:Michael D
thread:128125
URL: http://www.dr-bob.org/babble/20021116/msgs/128125.html