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Re: Substance P drugs ... Mifepristone » glenn

Posted by Bob on October 3, 2002, at 18:49:47

In reply to Re: Substance P drugs and CRF antagonists?, posted by glenn on October 3, 2002, at 14:10:03

> Hi there,
> As far as I know the only substance p drug was dropped due to ineffectiveness, though there may be more, crf antagonists I beleive are in phase 2 testing , ie antalarmin and astressin, perhaps one of our american friends can say how long it takes from there to availability as I am from England so im not sure of their timetable.
> There are meds which act on cortisol which is one of the things crf drugs will affect, but they tend to be problematic, ie mifepristone, ketoconazole and I beleive thalidoimide- a fine bunch!
> glenn

Glenn:

Why are drugs like mifepristone and ketoconazole "problematic"? I'd be especially interested to hear your opinion concerning mifepristone, as my pdoc was willing to try me on it.


 

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