Posted by Silly Brain on September 19, 2002, at 13:05:53
In reply to Re: Unresponsive to SSRIs? What worked?, posted by oracle on September 19, 2002, at 9:50:38
> Ignore dopamine, unless you are taking an AP. AD's that list action with dopamine don't really have much, or one would get TD, EPS and other nasty effects.
I'm not sure I understand. Dopamine is affected by stimulants/amphetamines, such as ritalin, dexedrine, adderall...and before they were given to hyper kids for focus they were given to depressed housewives for lack of motivation. In fact, an ad from the 60s refers to Dexedrine Spansule as the model antidepressent. That's far from the AP effects on dopamine, but still dopamine stimulating all the same. My understanding is that Wellbutrin has somewhat less stimulating effects on dopamine than amphetamines.
> The judy for me is still out on Wellby and NE. Action is there but I think it is much. In Effexor, and doses under 150 mgs, it is the most powerful 5HT agent we have, above 150 it becomes a powerful NE agent.At 300-450 it is the most powerful NE agent I have taken.
How do you know you are getting an NE effect as opposed to a 5HT effect? One speculation I heard is that SSRIs make people more resilient and tolerant of stress, but this doesn't really address the darkness and demotivation of depression.