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Re: L-tyrosine for stim-induced dopamine depletion » oracle

Posted by Jerrympls on August 22, 2002, at 22:39:51

In reply to Re: L-tyrosine for stim-induced dopamine depletion, posted by oracle on August 22, 2002, at 11:42:43

> > They don't? I've had many pdocs tell me that stimulants cause receptor burn out and drain the supply of dopamine, etc. Are those facts untrue? I wouldn't be suprised as the docs who have told me this were those "I'm not going to prescribe stimulants or anything addicted because I'll get my license revoked...blah blah blah."
>
> However many pdoc say just to oppsite. I have only heard this in persons who abuse amphetamine
> for years at very high doses.
> >
> > What does deplete dopamine?
>
> It is helpful to stop using the work "deplete"
> in assoc with NT's. Parkinsons kills off dopamine
> receptors/sites.
>
>
>
>

Hmm. Interesting. I feel - and please correct me if I am mistaken - as if you interpreted my message as some sort of challenge. Perhaps I should have been more basic - If a depletion of dopamine does not occur, what accounts for the tolerance? It is well known that stimulants release NE and dopamine. Would you agree? I have not fully researched this as well as you have, but I would theorize that tolerance comes from post-synaptic downregulation among other events. What have you found while researching this?

Also, if I understand you correctly, because I have had a psychiatrist tell me he won't prescribe stimulants because "they cause receptor burn out" and/or "I'll lose my license.." that means - most likely - that I am an amphetamine junkie? If so, why wouldn't my doctor talk to me about my seemingly obvious problem with abusing stimulants and try to help me into rehab? Wouldn't it be wrong of the doctor to ignore the problem and instead excuse his/her way out of the situation with these apparently bogus claims of burn out, etc.? Interesting that one would would be guilty of such an addiction by simply asking a doctor about stimulant augmentation. I would find it rather odd and uncomfortable to hear a well-trained doctor become so instantly paranoid about his job safety after having simply asked about a common augmentation strategy. It seems as if you have done much careful study and/or have known many amphetamine abusers to throw such a blanket statement around. Fascinating.

Hmm, so, let's see - I should be careful about asking my doc what he thinks of "Tough-Actin' Tinactin" for athletes foot because he may get wind of my fungus fetish?

Brilliant.


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poster:Jerrympls thread:117200
URL: http://www.dr-bob.org/babble/20020821/msgs/117449.html