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Re: Nardil + imipramine = SS

Posted by SLS on August 7, 2002, at 7:54:42

In reply to Re: Nardil + imipramine = SS SLS, posted by Iago Camboa on August 6, 2002, at 2:47:35

Hi Iago.

> Ouch! I'm sure it was no 'sweet pear' that one! Are you defying the devil? 300mg imipramine and 60mg phenelzine even carefully titrated (let alone the Lamictal) may be enough to knock out a
bison! I think you are lucky to be alive...

I wish I were a bison. Using such combinations over the last 12 years have not made much of a dent in my condition. In fact, I often feel nothing at all when using them - no stimulation of any kind.

I have not been particularly fearful of taking such combinations. I have been treated with similar regimes in the past.

> How have you proceeded? Did you lay down on bed and waited it to end?

Well, I have pretty much been laying in bed for two decades waiting for the beast of depression to be driven away. I did have to remain recumbent because the low blood pressure resulting from the combination of Nardil and imipramine did not allow me to stand up without passing out. However, this effect is probably related to the NE alpha1 blocking and anticholinergic effects of imipramine rather than serotonin syndrome. I found that the quickest way to relieve this condition along with the serotonin syndrome was to discontinue the imipramine. It takes a long time for the MAO inhibition action of Nardil and Parnate to dissipate. It was quicker to reduce the serotonin reuptake inhibition produced by imipramine by stopping it.

> Had your doc provided some pill for just in case?

No, but that's an excellent idea. I'll ask my doctor about it next week when I see him. Over the last few years, I have seen several different remedies suggested for serotonin syndrome. I wish I had written them down.

> Have you any stubborn treatment-resistent depression? Have you tried Nardil + Dexedrine + Lamictal? Or clomipramine/Anafranil + Dexedrine + Lamictal?

I have a very refractory case of a severe and chronic unremitting bipolar depression. Unfortunately, a desparate situation requires desparate measures. I had once taken a combination of Parnate 150mg + desipramine 300mg + amphetamine 20mg + thyroxine (T4).

The only thing that ever worked well and for more that just a few weeks was a combination of Parnate 60mg + desipramine 150mg. Unfortunately, my doctor at the time decided to discontinue my medication after only 9 months. I relapsed within 2 months and have not responded to the same combination since. Damn. It's hard to believe that such a seemingly small treatment decision has cost me so much.

> I wish you the very best of luck.

Thanks, Iago.





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