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Re: Melatonin - EFFEXOR COMBO

Posted by Fuscia on August 5, 2002, at 12:38:09

In reply to Re: SERZONE - EFFEXOR COMBO - please help, posted by ben on August 5, 2002, at 0:56:13

Hi Ben,

"Insomnia from Serzone ? I wonder why, but all is possible with ADs as I experienced." The reason Serzone can cause insomnia, mainly at higher doses, is partly because of one of its metabolites, m-chlorophenylpiperazine (mCPP), which can have anxiety-producing effects. Trazodone also has this same metabolite. Serzone also has some affinity for alpha 1 adrenergic receptors which can cause anxiety and insomnia. Of the two closely related antidepressants; trazodone and nefazodone (Serzone), trazodone is more sedating and so the better choice for antidepressant-induced insomnia.

Melatonin can be a good choice, but for some it can actually cause anxiety and restlessness, so no sleep. Its a hormone substance, so be certain to start out at the lowest dose that helps, 1.5mg taken two hours or less before bedtime. If this is not effective, gradually increase the dosage until and effective level is reached (up to 5mg daily). This natural hormone should only be used occasionally, since there is still much unknown about long term use. It shouldn't be used by people with autoimmune diseases, and cancer. There is a sublingual (under the tongue)form available if you have malabsorption problems, as well as a timed-release form if you frequently awaken after several hours' sleep. If you experience grogginess and feel tired in the morning - reduce the dosage.

A very good choice to help with a good night's sleep is calcium citrate 500mg, with added vitamin D to aid in abosorption of calcium - taken at bedtime. On occasion I use an herbal mix product called Hops-Valerian (by Nature's Herbs, 4 capsules contain herbal blend of hops flowers and valerian root as well as skullcap, 400mg each. Recommended dosage is 4 capsules at bedtime, but I take 2.) It works great for me.


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