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Re: MORE HELP WITH TERMINOLOGY PLEASE » DiscoPuppy

Posted by GreatDaneBoy on June 26, 2002, at 10:44:13

In reply to Re: MORE HELP WITH TERMINOLOGY PLEASE » DiscoPuppy, posted by Cam W. on June 26, 2002, at 4:19:31

Hi all!

I too have a question about dopamine antagonists and anti-psychotic drugs. If these drugs block dopamine action, then it would seem that it would not be a great idea to combine them with Wellbutrin, which I understand increases dopamine activity. I ask because a friend of mine is taking both Zyprexa and Wellbutrin. Is this weird or do I just not get it?

Thanks to everyone on this board for sharing all of your wisdom!!!

Dane =)


> An antagonist is a receptor blocker. Antagonists usually block, or at least dampen, electrical flow from one nerve cell to the nest.
>
> The antagonist molecule binds to a certain neurotransmitter receptor (eg. dopamine, serotonin, norepinephrine) and blocks (inhibits) the appropriate neurotransmitter from binding to it's receptor.
>
> If the neurotransmitter, which is released into the synaptic gap between 2 nerve cells, is not able to pass the electrical signal along nerves, thus decreasing the number and severity symptoms due to an excess of that neurotransmitter.
>
> For example; dopamine antagonist usually refers to a "Dopamine-type2-receptor blocker". Examples of these are the traditional antipsychotics like Largactil™ (chlorpromazine); Mellaril™/Thorazine™ (thioridazine); Haldol™ (haloperidol), and the newer mood-stabilizing antipsychotics like Risperdal™ (riperidone); Zyprexa™ (olanzapine); Clozaril™ (clozapine), and the rest.
>
> Psychoses is thought to be caused by a faulty, perhaps oversensitive &/or overactive, dopamine system. By blocking dopamine-D2-receptors, the overactive dopamine signal is muted, and there is, hopefully, a corresponding drop in the symptoms of psychosis.
>
> I hope that this is of some help. - Cam
>
>
>
> > what is an "antagonist" (as in "dopamine antagonist") and is it easy to explain in everyday language?
> >
> > -puppy-


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URL: http://www.dr-bob.org/babble/20020617/msgs/110815.html