Posted by JohnX2 on June 22, 2002, at 17:19:06
In reply to Re: ok, here is the cyp2d6 dopamine hypothesis, posted by Anna Laura on June 22, 2002, at 7:44:59
Anna Laura,I think the most likely explanation of the EPS is
a drug interaction between Wellbutrin and Effexor.Although the 2d6 dopamine hypthesis may contribute
to this, I don't know how 2d6 inhibition affects
dopamine in the brain (still curious and looking
into that).There are alpha-1 (noradrenaline) recptors on
serotonin neurons in a part of the brain
(the noradrenaline diffuses over from a neighboring site).
These alpha-1 receptors increase the firing rate of the serotonin
neurons. This is part of Effexor's mode of action.
Wellbutrin also increases noradrenaline and it
could also contribute to the increased serotonin
action.Anyways usually serotonin hyperactivity has been
associated also with TD/EPS. Blockade of the
serotonin 5ht-2a receptor is usually an antidote.There also may be a problem with Wellbutrin inhibiting
the excretion of a Effexor chemical, but I don't know
too much about this. Its noted in the article I
posted below.I'll get back to you on the other questions....
John
poster:JohnX2
thread:110261
URL: http://www.dr-bob.org/babble/20020617/msgs/110499.html