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Re: dopamine to noradrenaline Ritch

Posted by Iago Camboa on June 6, 2002, at 14:09:50

In reply to Re: dopamine to noradrenaline turalizz, posted by Ritch on June 6, 2002, at 10:15:37

> > Hi,
> >
> > Selegiline, in the MAO-B selective dose range would increase the dopamine levels, and since dopamine is the precursor to noradrenaline, selegiline would also effect noradrenergic transmission indirectly. Am I wrong?
> >
> > cem
> Yes, it would. Perhaps a more important player is one of selegiline's metabolites-methamphetamine. That one definitely releases noradrenaline and blocks its reuptake.
> Mitch

Unfortunately both amphetamine and methamphetamine (which are indeed selegiline's metabolites) are produced in amounts far too tiny to have ANY practical value whatsoever (either therapeutic or recreational).





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