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Re: Despiramine » Leighwit

Posted by JohnX2 on June 3, 2002, at 21:02:47

In reply to Re: Despiramine » JohnX2, posted by Leighwit on June 3, 2002, at 11:59:20


Hi Laurie,

I haven't taken Desipramine. I've read some abstracts on its
modes of action is all. It is a medicine I may be interested in
taking. I don't know much about Norpramin.

Take Care,
John


> John,
>
> Have you taken desipramine? I haven't read many of your posts; maybe you're extremely knowledgeable about these medications in general (great post to geno.)
>
> If you have taken it, I wondered if you knew of any differences between Norpramin and Desiprimine.
>
> Thanks so much,
> Laurie
>
> > > Desipramine has been mind boggling for me. My pdoc says its good for sleep and anxiety, but it seems to boost more norepinephrine. Im not panicy on it, but i feel a tingly sensatioin through my head and raised heart rate. No social phobia benifits. I think adderal/ritalin or dexadrine are better for social states than desipramine. I dont like my heart racing, esp when working out.
> > >
> > > I dropped desip, and took some ritalin, which mad me feel a bit better, along with zoloft and klonopin. But i still dont have my zoloft to 100mg yet. Im still not out going social finatic as i wanna be.
> > > geno
> >
> >
> > Are you taking this Desipramine with Remeron?
> >
> > The Desipramine is a norepinephrine reuptake inhibitor.
> > In a key stress area of the brain called the locus coeruleus,
> > the firing rate of neurons is somewhat directly related to
> > stress/heart rate etc. Usually over time NRI's in this area
> > will increase norepinephrine in the synapse but slow down the
> > firing rate by desensitizing norepinephrine alpha-2 feedback receptors.
> > This helps with depression and anxiety.
> >
> > Now Remeron blocks those alpha-2 feedback receptors, causing
> > an increase in norepinephrine release and firing rate on top
> > of the Desipramine reuptake inhibition maybe negating the
> > whole gig. Just a hypothesis on my behalf.
> >
> > Pure blockade of alpha-2 norepinephrine receptors themselves have
> > been shown to induce panic attacks (like taking yohimbine
> > for some people). Remerons anxiolytic serotonergic action
> > helps to negate this. (I believe this is the case don't quote
> > me).
> >
> > John


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