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Re: Pressor effects and response » IsoM

Posted by manowar on May 15, 2002, at 13:04:07

In reply to Pressor effects and response » manowar, posted by IsoM on May 15, 2002, at 1:53:38

> > > "BTW: Can someone tell me what this means:
> 'It increases the pressor effect of norepinephrine but blocks the pressor response of phenethylamine.'?
> What does pressor effect and pressor response mean?"
> It basically means that nortriptyline constricts small blood vessels, raises blood pressure, speeds heart rate, & similar effects that one gets from noradrenaline, or norepinephrine, (the pressor effect) & blocks the elevated blood pressure & quickened heart rate (the pressor response) caused by phenethylamine-type drugs like MDMA. So strangely, while it works with nortriptyline to raise blood pressure, etc, it'll also block these same effects caused by MDMA.
> An 'effect' is what's expected from normal hormones.
> A 'response' is the effects from certain meds.

Hello IsoM,
Thanks, and nice to 'see' you again. I hope all is well. I'm sorry for my ignorance, but I'm totally confused by your response. Excuse me for being a complete DA, but here goes:

First off, I thought the mechanism of MDMA is a release of Serotonin flooding the brain, not Phenethylamine. No?

Secondly, are you saying that the effects of increased phenethylamine (due to reuptake inhibition-I assume) is the opposite of the effects of increased noradrenalin (constricts small blood vessels, raises blood pressure, speeds heart rate, & similar effects), therefore canceling each other out?

Thirdly, it seems as if the pressor effect and the pressor response do the same thing, just that the ‘effect’ is natural and the ‘response’ is attributed to the drug. Correct?

All I really know about neurotransmitters and their role in depression is this:
1) The neurotransmitters that are mostly implicated in depression are (in order of importance)- Serotonin, Noradrenaline, Dopamine.
2) Also, phenethylamine and acetylcholine to some extent.
1) That their reuptake can be blocked, which keeps them in the synapse longer which in theory helps alleviate depression.
2) A MAOI does the same thing-just a different mechanism.
Is this correct?

BTW: I know—‘there are no stupid questions, just stupid people’:)




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