Posted by Ritch on May 13, 2002, at 22:31:14
In reply to Re: imipramine-(Mitch), posted by johnj on May 13, 2002, at 15:59:15
> Hi Mitch:
> I saw your question regarding imipramine and thought I would respond. I take 50 mg of nortryptline and have had some problmes with orth h. and also problems excercising. So, I tried remeron(too harsh), and now am at 20 mg of imipramine. I can say it has helped me sleep and feel better with no side effects. I think this may be because the norty. has always given me trouble so any light side effects at such a low dose probably are not noticable. I will be slowing weaning off the nort and switching to imip. I have like it thus far and I think is worth a trail. take care.
Thanks for responding. I doubt if I could tolerate 150mg of imipramine because of bipolar (thanks for the info Lia)-that is interesting John that you also are finding the imipramine more tolerable as well as Lia. I never got to 50mg of NT/day, but I did get to 30mg/day with Zoloft boosting it (via CYP2D6 inhibition). I have two quibbles about TCA's: 1) they tend to cause hiatal hernias (which I first got from high dose doxepin long ago), and 2) they elevate my heart rate quite a bit sometimes (with OH on the doxepin). I hope I can get 10mg *tablets* generic (probably caps-like nortripytline though). That way I can cut a tab in half and start off that way (I am sensitive to anticholinergic sfx big time). My next major depressive episode is going to start kicking in sometime between 3-6 weeks from now and I have got to get prepared (batten down the hatches!). It will have to be TCA, Provigil, or a sustained release pstim it appears, in addition to Depakote/Neurontin, etc.
thanks again for responding,