Posted by Lia Mason on May 12, 2002, at 23:18:01
In reply to No resp.=Depress-severe/Need help w/ old ADs!, posted by 3 Beer Effect on May 12, 2002, at 6:12:51
You probably already know this, but... it is not uncommon to require high doses of sam-e for depression. I did great with sam-e, but not til I got to 1200. That's expensive, but it did work.
I'm of the fatiguing depression type, too. The MAO's were great, but I couldn't take the side effects. I'm on a combo of sam-e and imipramine now. Re: orthostatic hypo... I had it bad on Nortriptyline and Nardil and it's very minor on imipramine. I hardly notice it. Imipramine is also a lot less sedating than Nortriptyline for me. The drag with these drugs (tricyclics) is that you can bypass side effects by going up very slowly, but that means you take A LONG time to reach a therapeutic dose.
If you can tolerate Wellbutrin it's worth a shot. It made me jittery, but most reports I've heard are quite positive.
Hang in. Good Luck.