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Re: SSRI's - why they loose their effect...

Posted by tex1 on April 24, 2002, at 3:03:48

In reply to Re: SSRI's - general question, posted by tex1 on April 23, 2002, at 17:18:51

> > hmm. peak after a few days?
> > always poop out?
> >
> > i'm not sure this is representative of most people's experience with AD's. some take several weeks to kick in, and for many, the AD effect lasts for many years.

See, what I believe about ADs effect depends on the serotonin level in the synapse. We all have some negative feedback inside our body. Receptors downregulation is just one of these. According to what is commonly believed about depression, this illnes is due to an imbalance in the serotonine trasmission. Deeper to a decrease in the serotonine concentration in the synapse. Now, what SSRI do is just to increase the serotonin levels. But with time here is the receptors downregulation. Some say that that this is the beginning of the therapeutic effect. I don' think so. The beginning of therapeutic effect is when in the synapse you have more serotonin. That's it. So, the body reacts by depleting receptors caused by an increased amount of serotonin into the synapse. This is when the med starts to poop out. It all depends on how much time does your body reacts to an increased amount of serotonin. Some people takes months, some jsut weeks. That's it.

Tex



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URL: http://www.dr-bob.org/babble/20020416/msgs/103974.html