Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: More about MAOI's! djmmm

Posted by Elizabeth on April 4, 2002, at 22:08:53

In reply to Re: CHRISTOPH: More about MAOI's!, posted by djmmm on April 3, 2002, at 7:04:13

> As far as I know Parnate is also an irreversible MAOI.

Yeah, that's my understanding too. Irreversible enzyme inhibition just means that the drug interacts with the enzyme (here, MAO) in such a way that the enzyme is effectively "destroyed," as opposed to competitive or reversible inhibitors, which tack onto the enzyme but can be displaced by other substrates if high enough concentrations (of the other substrate, that is) are present. I'm not very up on biochemistry, but I believe that the "bond" formed isn't an ordinary covalent bond -- enzymes like MAO are big, complicated molecules that interact in big, complicated ways. (Nardil and Parnate themselves are pretty simple though -- both of them are very similar to amphetamine.)

Irreversible enzyme inhibitors are also sometimes called "suicide inhibitors," which is either very appropriate or in very poor taste (I can't decide which) when applied to an antidepressant.

> Parnate has a rather short half life, but active metabolites, and these active metabolites also bond to MAO.

That's interesting. I didn't know that anything was known about the metabolites of Parnate, except that they aren't amphetamine or methamphetamine.





Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Elizabeth thread:100948