Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: What Zyprexa is excellent for - Old School » Denise528

Posted by SLS on April 2, 2002, at 10:53:29

In reply to Re: What Zyprexa is excellent for - Old School, posted by Denise528 on April 2, 2002, at 9:08:02

> Thanks Scott,
> Thanks for the explanation, it's clear to me now. However, do SSRIs perform Antagonistic or Agonistic actions or are reuptake inhibitors different?
> Denise

In the most generic sense, an agonist promotes, and an antagonist inhibits, the event being referred to.

I have seen some authors of medical literature refer to a reuptake-inhibitor as an "indirect" agonist of postsynaptic receptors. These drugs do not attach directly to receptors, and are thus not considered to be receptor ligands. That a serotonin reuptake inhibitor drug like Prozac increases the amount of serotonin in the synaptic cleft (the gap between the pre- and post- synaptic neurons), it causes an increase in the rate of stimulation of the attendant serotonin receptors, as long as these receptors are not also antagonized (blocked) by the same drug. The drug therefore is an agonist of serotonergic receptor stimulation. I do not like this usage of the words "agonist" and "antagonist". They are usually reserved for receptor ligands.

LIGAND: An ion, a molecule, or a molecular group that binds to another chemical entity to form a larger complex. (The American Heritage® Dictionary)

DA (dopamine) antagonists: Zyprexa, Risperdal, Haldol, Thorazine - neuroleptic antipsychotics

DA agonists: Mirapex, Parlodel, Permax, Requip... - anti-parkinsons drugs


5-HT = serotonin

Among other things, Serzone does the following:

1. inhibits 5-HT reuptake
2. antagonizes 5-HT2 receptors

The net effect is that Serzone promotes an increase in the stimulation of 5-HT1 and 5-HT3 receptors, but a decrease in the stimulation of 5-HT2 receptors.

That's enough thinking for today. My brain hurts.


- Scott




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:100817