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Re: phentermine and Effexor - djmmm

Posted by djmmm on March 28, 2002, at 13:02:40

In reply to Re: phentermine and Effexor - djmmm, posted by Bekka H. on March 28, 2002, at 10:44:34

There are so many things wrong with the phen/fen combo..

The main problem was that phentermine increased levels of catecholamines (dopamine, norepinephrine)and inhibiting monoamine oxidase (not very potently)... fenfluramine was increasing serotonin levels by *stimulating* the release, and blocking the re-uptake; fenfluramine also increased blood levels of serotonin.

also, both drugs are known neurotoxins...phentermine is neurotoxic to dopamine neurons, and fenfluramine is neurotoxic to serotonin neurons (via the exact mechanism as MDMA--the drug ecstacy)

...to compound this, some studies show phentermine increased the neurotoxicity of fenfluramine..

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9776127&dopt=Abstract


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