Posted by SLS on March 28, 2002, at 8:29:58
In reply to Re: Do Lamictal Provigil counteract each other? » 3 Beer Effect, posted by JohnX2 on March 27, 2002, at 4:57:58
I wrote this along another thread:
John, it is almost scary how similarly we react to drugs. I bet Serzone would work for me (partially or otherwise). I am guessing that my positive reaction to Zyprexa, Risperdal, and Geodon were in large part due to their 5-HT2a antagonism.
> Did you get a dopamine kick from provigil?
> That medicine worked for 2 hrs for me before pooping out!
> I've looked at this stupid poopout thing inside out.
> Adderall would poopout in 3 days like clockwork,
Me too with Dexedrine - on several occasions. 3 days.
I think there may be some profound significance to the number of days that these responses last - 3. For me, 3 days is exactly how long my transient responses to TCAs, MAOIs, and inoffensive have been. This has been a consistent phenomenon for me over the 20 years that I have been treated.
I have seen the number "3" pop up quite frequently on Psycho-Babble.
It is possible that the number "3" is the key to our doors.
While I'm here, I would like to offer another opportunity for discovery. The existence of a therapeutic window for nortriptyline to the exclusion of all other TCAs might provide for the identification of a specific phenomenon by which depression is both perpetuated and successfully treated.
> except when co-administered with Klonopin, a GabaA agonist. Then it was smooth sailing at 40 mg/day (until Klonopin shit on me).
What about Gabitril? Or perhaps Gabitril + Neurontin (if Neurontin promotes GABA synthesis as some have suggested).
Neurontin = Accelerated synthesis of GABA
Gabitril = GABA reuptake inhibition
I am still dubious of the notion that Neurontin increases GABA synthesis. Can you find more information with regard to the pharmacologic properties that Neurontin displays? Although Neurontin can provide me an improvement upon the initiation of treatment, I get all whacked-out and zombie-like within a week or two. I don't know whether this phenomenon is dosage dependant or time-dependant. It occurs at dosages as low as 900mg, and does not appear to mitigate with time.
Oh, and another thing in re poop-out (tachyphylaxis). It almost seems as if the system simply runs out of gas - what little stores of DA that are available are quickly depleted. Here's an observation about my depressed state. It quickly worsens *significantly* upon an attempt to read more than a few paragraphs. It actually "feels" as if I run out of gas. The worsened state most often lasts for hours - or even the balance of the day. I really do think that something is going on presynaptically that prevents an adequate synthesis of dopamine. Have you ever encountered an experiment that attempts to assay tyrosine-hydroxylase activity?