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Re: Provigil for cognition? Yesss!

Posted by SLS on March 28, 2002, at 7:18:17

In reply to Re: Provigil for cognition? Yesss!, posted by jazzdog on March 27, 2002, at 20:01:51

> In another thread, there's some speculation that lamictal and provigil might eventually counteract one another because one stimulates glutamate and the other reduces it...
> - Jane


This was my initial concern as well when I tried the combination almost two years ago. Sometimes it pays handsomely to be dumb. Sometimes not. In this case, I would also like simply to know how someone else responded to the combination. My ability to best evaluate my trial of Provigil was confounded by my having started taking sulpiride the week prior. (A neuroleptic antipsychotic with antidepressant properties at low dosages). I was taking Lamictal 300mg at the time. Within an hour of my first 100mg dosage of Provigil, I felt a significant improvement. It lasted for one or two hours, but this is sometimes exactly what becomes a positive prognosticator of future long-term response. Unfortunately, I abandoned the trial after only three days when I began to feel like a zombie and experienced a great deal of anxiety, which is uncharacteristic of me. I discontinued both sulpiride and Provigil on the same day. For the next two weeks, I felt much worse than I could account for by my baseline depression. I blamed Provigil and its possibly antagonistic effects to Lamictal. Of course, I can't be sure because I changed two things at once. It could just as easily have been sulpiride. Not smart.

The "smart" part of me still leans in favor of blaming Provigil, but my reactions to some drugs are atypical. Sometimes, one drug will kick another out of bed (an untenable metaphor that I'm too lazy to replace). The offending drug somehow changes the dynamics of the system and renders a previously helpful drug regime useless. This is not a common occurrence, though.

- Scott




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