Posted by JohnX2 on March 26, 2002, at 18:12:43
In reply to modafinil: glutamate and gaba blockade 2, posted by JohnX2 on March 26, 2002, at 18:09:13
1: Neuroreport 1997 Sep 8;8(13):2883-7 Related Articles, Books, LinkOut
The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus.
Ferraro L, Antonelli T, O'Connor WT, Tanganelli S, Rambert F, Fuxe K.
Department of Experimental and Clinical Medicine, University of Ferrara, Italy.
The antinarcoleptic drug modafinil [(diphenyl-methyl)-sulfinyl-2-acetamide; Modiodal] dose-dependently inhibits the activity of GABA neurons in the cerebral cortex and in the nucleus accumbens, as well as in sleep-related brain areas such as the medial preoptic area and the posterior hypothalamus. This study examined the effects of modafinil (30-300 mg/kg, i.p.) on dialysate glutamate and GABA levels in the ventromedial (VMT) and ventrolateral (VLT) thalamus and hippocampal formation (Hip) of the awake rat. The results show a maximal increase in glutamate release in these brain regions at the 100 mg/kg dose, associated with a lack of effect on GABA release. Thus modafinil may increase excitatory glutamatergic transmission in these regions, altering the balance between glutamate and GABA transmission.
PMID: 9376524 [PubMed - indexed for MEDLINE]