Posted by OldSchool on March 18, 2002, at 20:14:11
In reply to Re: Why do people prefer ssri's over Wellbutrin?, posted by djmmm on March 18, 2002, at 19:37:22
> Eric...Wellbutrin is weak in terms of potency; it's efficacy is similar to the SSRIs....I'm assuming that's what your Pdocs were trying to say...
>
> Wellbutrin has less incidences of poop-out because it doesn't increase serotonin as much as the ssris...check out this link I found, it's in another post
>
> http://dr-bob.org/babble/20020318/msgs/98652.html
Hmmmm excess serotonin causes AD poopout? I never heard of that one before. That is an interesting website, Ive seen that one before. Those Neuropsychiatry guys seem to like high dose Buspar a lot, I saw on there those guys say super high dose buspar can be used for TD.As for antidepressant poopout, I dont really know what to believe in the end. Most of the stuff Ive read has said its gradual dopamine depletion that causes much of the SSRI poopout. But nobody really knows I have gotten the impression. It seems to be heavily guesswork and hypothesis stuff...nothing concrete. Arent you a pharmacy student? What do you learn in pharmacy school about the mechanism(s) of SSRI poopout?
I did find Wellbutrin pooped out much less than serotonergic drugs. Its been years since I have taken it though. I did make my first semi-recovery on it strangely...its supposed to be this "weak" antidepressant I didnt find it was weak at all. I was also taking a lot of benadryl for insomnia when I made my first semi-recovery on Wellbutrin. It was more steady, it had a mild stimulant effect that just kept going and going. It wasnt any stronger than the SSRIs, just more steady and not the fadeout. With the problems I have now, I should probably switch back to Wellbutrin SR as my AD. It doesnt really have any real side effects.
Old School
poster:OldSchool
thread:98340
URL: http://www.dr-bob.org/babble/20020318/msgs/98661.html