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Re: Weight Gain from TCAs and Benzos for Sleep

Posted by MB on March 18, 2002, at 15:07:18

In reply to Re: Weight Gain from TCAs and Benzos for Sleep » fachad, posted by JohnX2 on March 17, 2002, at 2:15:57


> Zyprexa and Serzone block the alpha-1 receptor but don't do squat with antihistamine (in fact Zyprexa is a bit pro-histamine).

My 2000 PDR says that "Olanzapine's antagonism of histamine H-1 receptors may explain the somnolence observed with this drug." Have they found out something new since then? Maybe time to get a new PDR.

Also, I was always under the impression that Serzone was low on the weight gain spectrum of the other serotonin potentiating drugs. I *did* hear a seminar once where it was proposed that adrenergic a-1 blockade might be partly responsible for weight gain seen with use of some neuroleptics. When I read that Serzone blocked a-1 I was a little dismayed (actually I was dismayed before then: when I stood up out of bed after my first nightly dose of 200mg--titrated up to there--and I passed out and hit my head). Orthostatic hypotention and sluggish metabolism and possible liver failure, well, sucks. I haven't gotten fat thanks to Adderall...but that may not last much longer, I don't know.

MB


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URL: http://www.dr-bob.org/babble/20020318/msgs/98604.html