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Re: High Dose Prozac » johnX2

Posted by SLS on March 13, 2002, at 11:27:22

In reply to Re: High Dose Prozac » SLS, posted by johnX2 on March 13, 2002, at 7:23:48

Hi John.


> Hi Scott,
>
> Tecnically....
>
> If I'm reading this correctly the high dose Parnate does not "antagonize" so to speak the 5-ht2 receptors.


Yes, I know. I followed up my first post with an "Oops" post. It had been awhile since I read the thing. I knew that it had something to do with something doing something to something else, so I was pretty close. :-)

The chronic, but not acute, administration of some other antidepressants also produce a downregulation of 5-HT2 receptors. Such is also the case with other types of receptors. NE beta receptor downregulation had been the focus for many years, but I don't know if any explanation as to its relevance has been established. It's just that these compensatory changes take two weeks to appear, a time course that coincides with the two weeks it usually takes for someone to respond to most antidepressant medications. I know you know this stuff. I just wanted to make sure that I did.

- Scott

 

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