Posted by Elizabeth on February 28, 2002, at 1:30:07
In reply to Re: spontaneous htn from Parnate » Elizabeth, posted by christophrejmc on February 26, 2002, at 21:51:53
> Do you have any idea why some people get spontaneous hypertension from Parnate (I think you once mentioned that your bp increased slightly even from 10mg, so I'm guessing it's not dose-dependent...)?
It is dose-dependent. My BP only increases very modestly after a 10 mg dose, but if I take 20 mg, it increases significantly, and 30 mg is quite likely to have nasty consequences.
As to why: there has been some speculation that Parnate has a metabolite that works like amphetamine, a DA/NE release enhancer. It might be that in some people, Parnate potentiates its own metabolite, causing elevated blood pressure.
> It's strange that people who have experienced this can add other sympathomimetics like amphetamine without a significant rise in bp.
Err, I had problems when I tried that! (Adderall 1.25 mg was okay....)
> I guess it's something that no-one really cares about researching, but it would probably be helpful to figure out.
Yeah, it is too bad that nobody cares enough to do research on the old drugs. I'd like to know the answer to this one too.
-elizabeth
poster:Elizabeth
thread:95075
URL: http://www.dr-bob.org/babble/20020222/msgs/95778.html