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Re: anyone anxious on pindolol? » paulb

Posted by JohnX2 on February 25, 2002, at 19:41:01

In reply to Re: anyone anxious on pindolol?, posted by paulb on February 25, 2002, at 18:38:44


paulb,

I thought about the 5ht-1a blockade. I've always wondered
why propranolol doesn't share the same AD property as
pindolol. I guess this has stymied scientist. I wonder
if it does have something to do with the full beta blockade
getting in the way of an anti-depressant response.

-John

> Pinodol may have caused you to become
> hypomanic after 3 days, and then petered out because it blocks the 5-HT1a auto-receptors that control the release of serotonin. If they are blocked then more serotonin is released via a negative feedback loop. OOnce your brain adjusted to the increase in 5-HT then that may be the reason it petered out. Just a theory. But the auto-receptor blockade is what makes pinodol special among the beta-blockers. Blockade of the 5-HT1a post-synaptic receptors could also cause further serotonin activity at other receptor causing hypomania but propranalol has the same property so I would assume it was the auto-receptor blockade, an antidepressant mechanism comparable with MAO inhibition and monoamine re-uptake. Just think of Mirtazapine.
> paulb


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URL: http://www.dr-bob.org/babble/20020222/msgs/95500.html