Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Zanaflex and dystonia/twitching relief

Posted by JohnX2 on February 23, 2002, at 22:59:59

In reply to post zyprexa hand twitching and clenching????, posted by JohnX2 on February 23, 2002, at 14:37:54


I've been taking Zanaflex (tizanidine), which
is basically a Clonidine dirivative, a partial
alpha-2 noradrenergic agonist. The Zanaflex was
prescribed to help with myofacial pain a while
back. I subsequently got Topamax which worked
much better, but when I got down to tapering
the last few crums of Klonopin I restared the
Zanflex (shitty halflife requires multiple dosing)
and I noticed a substantial amerlioration of
the dystonia. clenching and twitching/tremor
virtually disappeared.

I since read that Clonidine is a decent treatment
for TD and that there are thoughts that TD
can cause toxic incread turnover in catecholimines.
The Zanaflex being an Alpha-2 agonist decreases/stabilizes
catacholinergic transmission. I wish there was a
patch sustained release version of the medicine
like clonidine. It had no hypotensive side effects.


> I picked up this hand clenching and twitching
> while manic and drinking lots of caffeine and
> clenching my fist driving my car a lot and
> playing a lot of golf all last month. I was also
> taking a whopper dose of Zyprexa to battle the
> mania. After a while I started to get bad spasms
> in my left hand while I was having these bad manias
> and I got cramps in my hand concurrent with the activities
> (holding my steering wheel or golf club).
> This problem seemed to come and go with the mania
> and stimulant abuse and clenching motions and I
> discussed it with my pdoc. We felt it was probably
> just some sort of Klonopin withdrawl seizures. Well
> now I stopped Zyprexa and I am getting off/on
> clenching and twitching in my hands. Mostly off.
> Like 95% of the day I am Ok. If I drink some caffeine
> and do some clenching motions it may start up again
> and I freak out. I have gotton twitches in my face
> that have persisted for months and then vanished. Is this
> just some sort of tardive dystonia like thingy that
> is likely to go poof over a few months like my other
> little twitches normally would? This one is much
> bigger, my whole hand is involved, fortunately not
> my dominant hand, but I'm still nervous.
> -John




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:JohnX2 thread:95227