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Re: New Celexa...BORING! @ OldSchool

Posted by djmmm on February 5, 2002, at 22:44:52

In reply to Re: New Celexa...BORING! @ OldSchool, posted by OldSchool on February 5, 2002, at 20:58:49

> > Cheese like effect: Tyramine is like a prodrug of noradrenaline, so eating food including much tyramine elevates the noradrenaline level. MAOIs inhibit the turn over to inactive metabolites of noradrenaline (dopamine and serotonin) like 3-OH-noradrenaline. MAOIs do influence the MAO in the brain much more than in the liver (plasma levels of of monamines are not very high compared with concentrations in the brain) Patches do only affect the first pass metabolism in the liver so you have do give less amounts of the drug reaching a similar plasma level. So why should the patch do not have the cheese like effect ? The drug mechanism is the same, as well as the final elimination through the liver.¨
> >
>
>
> Look Ben, this stuff isnt my idea. I am just repeating stuff Ive read about this MAOI patch. The FDA pulled the MAOI diet requirements in the clinical trials for this patch. The things Ive read about it say the drug bypasses the gut, unlike with oral forms of MAOIs and this eliminates the need for the MAOI diet.
>
> This link explains some of it:
>
> http://www.news.harvard.edu/gazette/1998/12.10/depression.html
>
> < quoted from above article >
>
> >The FDA eliminated dietary restrictions for >those in the new study, now getting under way. "When given through the skin, selegiline finally removes the need for such restrictions," >Bodkin says.
>
> Here is another link that mentions no need for the MAOI diet with the selegiline MAOI patch:
>
> http://www.mhsource.com/expert/exp1051500c.html
>
> >The "MAOI patch" is being tested at McLean >Hosptial in Belmont Mass, under the direction of >Dr. Alexander Bodkin. The patch uses an antidepressant called selegiline [Eldepryl], which is a MAOI (monoamine oxidase inhibitor). Unlike standard MAOI tablets, the "patch" bypasses the gut, and should allow a normal diet to be used by the patient. Keep in mind, of course, that standard MAOI tablets have been available for decades, and may be very helpful in some cases of severe, resistant depression; however, a special diet is required for their use, as you may know
>
> Eric


Eric,

also... by bypassing first pass metabolism, the l-amphetamine, and l-methamphetamine metablites are avoided...

Im confused because Selegiline is a poor antidepressant (typically), Do you know the amount of selegiline absorbed through the skin? is it high enough that it is no longer selective to MAO-B?....

...also you still have to avoid all the medications that are on the MAOI list (ephedra, dextromethorphan, ventolin, etc)

just some links:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7519005&dopt=Abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2491941&dopt=Abstract
)


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poster:djmmm thread:91928
URL: http://www.dr-bob.org/babble/20020131/msgs/93027.html