Posted by ben on February 4, 2002, at 13:07:42
In reply to Re: New Celexa...BORING!, posted by OldSchool on February 3, 2002, at 15:00:31
Hi OldSchool
Why should this be an improvement or breakthrough ? Selegiline is on the market since years and other MAOIs/RIMAs as well.
Pdocs are allowed to use Selegiline for depression without any FDA approval. And dont forget: if MAIOs/RIMAs would work great they would be more prescribed !!! It isnt only the fear of severe blood pression. Venlafaxine is the only one which has been superior to other ADs in several studys including faster onset of action. We dont have any real alternative to Venlafaxine (tricyclics are much more nastier concerning anticholinergic side-effects ) yet...so Duloxetine is welcome.
I agree that we have enough SSRIs and more new mechanisms (e.g. Venlafaxine, Nefadozone, Mirtazapine) should be developped. I read abou the company MERCK investigate an substance which acts like an SSRI BUT including blocking the 5HT1 receptor. From my experience SSRIs are hitting mood much more than Reboxetine/Desipramine....so the serotonine mechanism has to bee present for an AD. I dont know much about the MAO-B inhibitor Selegiline (parkinsons disease). Should it work better than Tranylcypromine or the RIMA Moclobemide ??? Give us some facts, that would be nice.thanks ben
> When is the Selegiline MAOI patch coming out? IS the MAOI patch going to be FDA approved? Now THERE is a real antidepressant!!
>
> Old School
poster:ben
thread:91928
URL: http://www.dr-bob.org/babble/20020131/msgs/92829.html