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Re: Only alcohol, benzos, selective for GABA-A??? » 3 Beer Effect

Posted by JohnX2 on February 2, 2002, at 20:31:32

In reply to Only alcohol, benzos, selective for GABA-A???, posted by 3 Beer Effect on February 2, 2002, at 16:56:08


Mr. 3 Beer,

The anti-convulsant Topamax increases Gaba-A conductance.

Btw, what is your favorite beer? ;).

-John

> I was looking at the gabitril.com website and it appears that the proven anxiolytic/social phobia drugs like alcohol, benzodiazepines, & the barbituates only affect GABA-A.
> http://www.gabitril.com/physicians/gaba/default.asp
>
> The Role of GABA in CNS:
> GABA binds to 3 principal receptors, each of which is involved in different physiologic functions:
>
> GABA-A receptors-- mediate fast inhibitory synaptic transmissions; they regulate neuronal excitability (eg, seizure threshold) and rapid changes in mood (eg, anxiety, panic, and response to stress); they are targets of benzodiazepines, barbiturates, and ethanol.
>
> GABA-B receptors mediate slow inhibitory potentials; they appear to be important in memory, mood (depression), and pain.
>
> GABA-C receptors –– their physiologic role has not yet been described.
>
>
> Since Gabitril is not selective for GABA-A, then would Gabitril cause "dumb drug" effects on memory?
>
> Is there a selective GABA-A agonist besides alcohol, benzos, or barbituatues?
>
> Also, I can't find the "MAOI of GABA" - Sabril (vigabatrine) in the 2002 Nurses Drug Guide or PDR. Is Sabril available in the United States yet? Is Sabril selective for GABA-A?


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URL: http://www.dr-bob.org/babble/20020131/msgs/92662.html