Posted by cmcdougall on January 23, 2002, at 9:22:57
In reply to Possible answers » MB, posted by TSA West on January 22, 2002, at 23:15:23
I take celexa, despipramine, and adderall. I worry about poop-out as it seems to always happen to me eventually. I have been thinking of augmenting w/ Memantine. This drug is supposed to protect the neurons from adapting to the SSRIs, Stims, etc. It is being tested for people w/ chronic pain who have to take a lot of opiates. This drug seems to prevent the need for dosage increases over time and inhibits opiate addiction. I think it is similar to Amantadine, an old anti-viral that is used for other indications now. Memantine has been used in Germany about 10 years for Alzheimers and senile dementia. Hey, if it improves my cognitive abilities and memory retention too, great. Maybe it will also help my libido...
I really like the drug combo I am on now and if I could take it indefinately w/out poop-out, I would be one happy girl.
> One possible answer is dopamine depletion over time with SSRIs: http://www.dr-bob.org/tips/split/Patients-who-lose-response.html
>
> Another answer is that peoples' metabolisms change over time such that a drug gets metabolized too fast, and the legal limits prohibit a doctor from prescribing more medication than the Physicians' Desk Reference allows.
>
> I don't think one can prove this happens as much with tricyclic antidepressants.
>
> Be well and prosper,
> TSA West, founder: William Booth ++++
poster:cmcdougall
thread:91095
URL: http://www.dr-bob.org/babble/20020116/msgs/91228.html