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Re: Mood-reactivity in atypical depression. » JohnX2

Posted by SLS on January 21, 2002, at 14:12:53

In reply to Re: Mood-reactivity in atypical depression. » SLS, posted by JohnX2 on January 21, 2002, at 1:57:34

Thanks so much for your post, John.
I will definitely keep Topomax in mind, then. My doctor brought up its use early in my treatment with him, but I don't know if he meant to use it as a supplement. I'm sure he would have kept the Lamictal on-board anyway, as it is one of the only drugs that makes a dent in an otherwise inpenetrable wall. That Topomax has enhanced your response to stimulants is exciting. I think I'll make sure to try it before giving up on Effexor.

What side effects do you notice with Topomax? In particular, what cognitive effects do you experience? Have they mitigated with time. The current posture on this issue is that a gradual titration can almost prevent the emergence of cognitive side effects and increase the chances of their eventual disappearance. How did you go about starting Topomax?

In re: Zyprexa. I seem to suffer a zombie-like cognitive blunting after reaching 5.0mg for several days. Risperdal and Geodon too. Do you have any thoughts on this? The thing that confuses me is that I tolerated Zyprexa 10mg well for a week or so a few years ago. At the time, it was used to put out a manic brush-fire. Maybe there is some sort of time-dependency involved in the emergence of this effect. Any thoughts? Otherwise, these atypical neuroleptics show signs of being particularly beneficial to me.

Currently:

Lamictal - 300mg
Effexor - 300mg
imipramine - initially, titrating to 200mg
(It is likely that IMI blood levels will be increased due to the interaction of Effexor with CYP450. Otherwise, 300mg will be the eventual target)


BTW, What are your thoughts on Gabitril?

I am SO glad that things are progressing splendidly for you. I was concerned for awhile when your name on PB was appearing less frequently.

HAVE FUN!!! Enjoy every moment of it.

Thanks again for your input.


Sincerely,
Scott

> Hi Scott,
>
> Sorry you feel crummy.
>
> Did you every get to try the Topamax + Lamictal
> experiment?
>
> Mine is going very well.
>
> I am taking:
>
> 400 mg Topamax
> 150 mg Lamictal
> 2.5 mg Klonopin
> 5 mg Zyprexa
>
> The Topamax addition FIXED my myofacial pain.
> Plus it seems to have MOPPED UP any residual
> depression. Plus I seem to have noticed that I
> DON'T HAVE stimulant tolerance issues. Plus
> I can take meds that would cause myofacial pain
> in the past (Wellbutrin), etc.....worth a try.
> I think the Topamax works well as an adjunct
> to Lamictal, but I'm not so sure how I would
> do on it stand alone.
>
>

 

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