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Re: MAOI efficacy » TSA West

Posted by SLS on January 19, 2002, at 11:54:52

In reply to MAOI efficacy » SLS, posted by TSA West on January 19, 2002, at 5:14:19

Hi TSA West.

> I wish you well.

Thanks. The more wishes the better...

> I think you're on the right track with MAOIs in general, considering that you had a response to Nardil in the past.

My doctor is determined to see what we can do with a regime built around Effexor. I am currently taking Lamictal 300mg, Effexor 300mg, and I am about to start imipramine. The initial target dosage of imipramine is 200mg. Generally, I seem to need 300mg to get from imipramine what it is willing to give up. However, it is likely that there will be a kinetic interaction between it and Effexor; Effexor reducing the clearance of imipramine and yielding higher blood-levels. We'll see. After this come adding Remeron and possibly Celexa. I don't have a good feeling about Remeron. Based upon my horrendous experience with idazoxan, another NE alpha-2 antagonist, I am not predicting good things. However, at this point I don't have the luxury of leaving any stones unturned.

> And further, your 'rejection-sensitivity' sounds a lot like Social Anxiety Disorder

Social anxiety has been a prominent feature of my depressed state. I wonder if there is a concordance between these two clinical descriptions. Are they different flavors of the same core symptom?

I think I will return to Nardil if we exhaust polypharmaceutical strategies that include Effexor. I must act under the supposition that Effexor + non-selective irreversible MAOI = death, or some facsimile thereof.

> I am glad that you have progressed in the learning of your emotions, such that you can present them to us-- and thus we can help you more thoroughly in your quest for a good medication regimen....
>
> TSA West^^^^^^^^^

Thanks.


- Scott

 

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