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Re: Decreased sexual drive and Celexa » Pnut

Posted by jimmygold70 on January 8, 2002, at 18:35:43

In reply to Re: Decreased sexual drive and Celexa » jimmygold70, posted by Pnut on January 8, 2002, at 10:32:04

> Thanks for the info, but I have read that I should not take Remeron and Celexa at the same time. How long have you taken this combination? Have you had any problems?
> I will talk to my doctor about this today...have you tried Ginko to eliviate some of the sexual side effects? Any help is greatly appreciated.


I have tried EVERYTHING (buspirone, amantdine, wellbutrin, cyproheptadine to name a few), and only mianserin (which is not available in the US for my best knowledge helped). Remeron is very similar to mianserin in its pharmacology and chemical structure. Avi Weizman, who did the research below, now recommend on low-dose Remeron (7.5-15mg). There is no problem to take it with Celexa.

Jimmy

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The serotonin antagonist mianserin for treatment of serotonin reuptake inhibitor-induced sexual dysfunction in women: an open-label add-on study.

Aizenberg D, Naor S, Zemishlany Z, Weizman A.

Geha Psychiatric Hospital, Petah Tiqva, Israel.

The aim of this study was to determine if the serotonin antagonist mianserin improves antidepressant-induced sexual dysfunction in women. The work was prompted by an earlier study of men by our team of researchers. The study population included 16 women aged 20-65 years undergoing treatment at a psychiatric outpatient clinic, who presented with sexual dysfunction subsequent to intake of a serotonin reuptake inhibitor (SRI) for depression. Sexual function (four domains) was evaluated by semistructured interviews before and after the administration of mianserin 15 mg/d for 3 weeks. The most prominent sexual dysfunction was anorgasmia. Clinically significant improvement was noted in all domains in two thirds of the patients, in most cases in the first or second week of treatment. None of the patients with panic disorder (PD) responded to mianserin, in contrast to those with affective disorder or obsessive compulsive disorder (OCD), indicating a possible relevance of the psychiatric diagnosis to mianserin effectiveness. There were no major adverse effects and no changes in the patients' stabilized psychiatric status. We conclude that mianserin is beneficial in reversing sexual function caused by SRI intake. Further large-scale, placebo-controlled studies are needed to confirm these findings.


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