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Re: Parnate dosing Elizabeth

Posted by christophrejmc on January 5, 2002, at 14:39:36

In reply to Re: Parnate dosing christophrejmc, posted by Elizabeth on January 5, 2002, at 2:13:23

> I had the same problem: couldn't take more than 10 mg in a single dose of Parnate because it would make my BP spike. (My baseline BP on Parnate was around 100/60; 20 mg of Parnate would send it upwards of 180/110). My BP still went up about a half hour after each 10 mg dose, but not nearly as much.

I notice the same thing (I'm usually a bit hypotensive off Parnate, so it's not much of a problem).

> I got up to 60 mg/day of Parnate (yes, 10 mg six times a day) but it wasn't enough and I was starting to have trouble taking all those separate doses. So then I tried desipramine, which worked about equally well but no better and would have required therapeutic serum level monitoring (I don't metabolize it normally). So now I'm giving Effexor another chance, and still sticking with the buprenorphine (along with Trileptal to prevent seizures and the occasional Xanax for anxiety/panic/jitters).

Do you mean you added desipramine to the Parnate, or took it alone? Desipramine (monotherapy) took a long time to kick in for me, but it seemed to make my depression worse (possibly because there was much to be unhappy about in my life at the time). MAOI+TCA is something I've been considering, but my doc is quite wimpy so I'm not sure if it'll ever happen.

> Do you find 40 mg/day adequate? I found that spacing them just two hours apart was enough.

I doubt it's doing much for me; I needed to get to a pretty high Nardil dose before noticing any effect, so I'm not sure I'll ever know if Parnate works for me. I don't think I want to try two hours apart -- I might be tempted to raise the dose + the number of effing pills I have to swallow.





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