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Re: RE: Using Serzone to Raise Levels of Other Meds dove

Posted by Rick on January 3, 2002, at 13:29:30

In reply to Re: RE: Using Serzone to Raise Levels of Other Meds, posted by dove on January 2, 2002, at 15:02:24

>It seems almost bizarre to me--as a prescribed consumer--that Serzone inhibits the very enzymes it needs for processing and elimination.

It is strange, but it's not at all uncommon. For example, one of the other meds I take, Provigil, is both an inhibitor (though less so than Serzone) and substrate of CYP3A4. At higher doses, it can sometimes induce its own metabolization. In other words, once in awhile it will reduce its own effectiveness. I've sometimes wondered if this is what's going on on the occasional days that Provigil doesn't seem to work as well for me, although I'm on a pretty conservative dosage.





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