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Re: escitaloproam

Posted by IsoM on December 19, 2001, at 3:03:31

In reply to escitaloproam, posted by geno on December 18, 2001, at 17:40:21

Seeing that this drug is Celexa but only the active form, not the combination of both right-handed & left-handed molecules. It would give the same benefits as Celexa does but with less side-effects, that's all.

> There will be a drug available called Escitalopram...It's called also
> anti-shyness drug...It is in fact a SSRI.But according to Claude
> Rifat's Theory it would be a good alternative for GHB in aspect of
> Socialness...(He was said that Depression is an illness caused by
> Anti-Social behaviour.).It is also very interesting that a drug
> increasing socialness.
> It is not available yet...Research info as:
> NEW ORLEANS, LA -- May 9, 2001 -- Escitalopram at 10 mg/day and 20
> mg/day demonstrated greater improvement relative to placebo at
> endpoint
> than citalopram in a U.S.-conducted, Phase III clinical trial of
> patients with major depressive disorder. Escitalopram, a single isomer
> of citalopram and a more potent and selective serotonin reuptake
> inhibitor (SSRI), showed consistent antidepressant effect across all
> efficacy measures at 10/mg day, a lower dose than currently indicated
> for any antidepressant of the SSRI class. This effective dose was
> exceptionally well-tolerated. The data were presented in New Orleans
> during a meeting of the American Psychiatric Association.
> "Based on the data, escitalopram shows great promise as a first-line
> treatment for major depression," said William Burke, MD, professor of
> psychiatry at the University of Nebraska Medical School and lead
> investigator of this study.
> In a randomized, double-blind, placebo-controlled, multicenter study,
> 491 patients with ongoing major depressive episodes were randomized
> for
> eight weeks to one of four trial arms: placebo, citalopram at 40
> mg/day,
> escitalopram at 10 mg/day and escitalopram at 20 mg/day. The male and
> female outpatients ranged from 18 to 65 years of age.
> The Montgomery-Asberg Depression Rating Scale (MADRS), which was the
> prospectively defined primary endpoint, showed that escitalopram at
> both
> 10 mg/day and 20 mg/day doses significantly separated from placebo
> beginning at week two and maintained that separation at all time
> points.
> On all other key outcome measures including the HAM-D, HAM-D item 1
> and
> CGI, escitalopram 10 and 20 mg/day statistically separated from
> placebo
> at either week one or two. At all time points, both escitalopram doses
> produced greater changes on the primary endpoint (MADRS) than
> citalopram
> 40 mg/day.
> Remarkably, there was no difference in the incidence of
> discontinuations
> due to adverse events between escitalopram 10 mg/day and placebo
> treatment (4.2 percent vs. 2.5 percent), or between escitalopram 20
> mg/day and citalopram treatment (10.4 percent vs. 8.8 percent).
> Escitalopram at both doses was well-tolerated, with a low incidence of
> adverse events such as nausea, diarrhea, insomnia and dry mouth.
> Dr. Burke noted that investigators have been especially pleased with
> the
> low discontinuation rates of escitalopram, and attribute it to its
> high
> tolerability.
> Certain chemicals in nature exist in two mirror-image forms, or
> isomers,
> which can be called right- and left-handed. Citalopram is a mixture of
> two mirror-image structures, an S- and R-isomer. The left-handed form,
> or S-isomer, is the active isomer in terms of its contribution to
> citalopram's antidepressant effects, while the R-isomer does not
> contribute to its antidepressant activity.
> Based on the clinical trial data, Forest Laboratories submitted a new
> drug application (NDA) on March 23, 2001 to the U.S. Food and Drug
> Administration seeking an indication for escitalopram for the
> treatment
> of depression.
> SOURCE: University of Nebraska Medical Center
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