Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ


Posted by geno on December 18, 2001, at 17:40:21

There will be a drug available called Escitalopram...It's called also
anti-shyness drug...It is in fact a SSRI.But according to Claude
Rifat's Theory it would be a good alternative for GHB in aspect of
Socialness...(He was said that Depression is an illness caused by
Anti-Social behaviour.).It is also very interesting that a drug
increasing socialness.

It is not available yet...Research info as:

NEW ORLEANS, LA -- May 9, 2001 -- Escitalopram at 10 mg/day and 20
mg/day demonstrated greater improvement relative to placebo at
than citalopram in a U.S.-conducted, Phase III clinical trial of
patients with major depressive disorder. Escitalopram, a single isomer
of citalopram and a more potent and selective serotonin reuptake
inhibitor (SSRI), showed consistent antidepressant effect across all
efficacy measures at 10/mg day, a lower dose than currently indicated
for any antidepressant of the SSRI class. This effective dose was
exceptionally well-tolerated. The data were presented in New Orleans
during a meeting of the American Psychiatric Association.

"Based on the data, escitalopram shows great promise as a first-line
treatment for major depression," said William Burke, MD, professor of
psychiatry at the University of Nebraska Medical School and lead
investigator of this study.

In a randomized, double-blind, placebo-controlled, multicenter study,
491 patients with ongoing major depressive episodes were randomized
eight weeks to one of four trial arms: placebo, citalopram at 40
escitalopram at 10 mg/day and escitalopram at 20 mg/day. The male and
female outpatients ranged from 18 to 65 years of age.

The Montgomery-Asberg Depression Rating Scale (MADRS), which was the
prospectively defined primary endpoint, showed that escitalopram at
10 mg/day and 20 mg/day doses significantly separated from placebo
beginning at week two and maintained that separation at all time
On all other key outcome measures including the HAM-D, HAM-D item 1
CGI, escitalopram 10 and 20 mg/day statistically separated from
at either week one or two. At all time points, both escitalopram doses
produced greater changes on the primary endpoint (MADRS) than
40 mg/day.

Remarkably, there was no difference in the incidence of
due to adverse events between escitalopram 10 mg/day and placebo
treatment (4.2 percent vs. 2.5 percent), or between escitalopram 20
mg/day and citalopram treatment (10.4 percent vs. 8.8 percent).
Escitalopram at both doses was well-tolerated, with a low incidence of
adverse events such as nausea, diarrhea, insomnia and dry mouth.

Dr. Burke noted that investigators have been especially pleased with
low discontinuation rates of escitalopram, and attribute it to its

Certain chemicals in nature exist in two mirror-image forms, or
which can be called right- and left-handed. Citalopram is a mixture of
two mirror-image structures, an S- and R-isomer. The left-handed form,
or S-isomer, is the active isomer in terms of its contribution to
citalopram's antidepressant effects, while the R-isomer does not
contribute to its antidepressant activity.

Based on the clinical trial data, Forest Laboratories submitted a new
drug application (NDA) on March 23, 2001 to the U.S. Food and Drug
Administration seeking an indication for escitalopram for the
of depression.

SOURCE: University of Nebraska Medical Center
Post a follow-up to this message

Google Home - Advertise with Us - Add Google to Your Site - News and Resources - Language Tools - Jobs, Press, Cool Stuff...

2001 Google




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:geno thread:87325