Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: klonopin 0.5 Cam W.

Posted by Elizabeth on December 13, 2001, at 20:34:31

In reply to Re: klonapin 0.5 undead, posted by Cam W. on December 13, 2001, at 16:22:56

> By crushing the tablets you are increasing the surface area, making the drug easier to absorb.

Duh! Thank you for explaining this. I should have been able to figure it out myself (really, I think I should have known it from somewhere or other), but it's always nice when someone who has a real grasp of this stuff intervenes with the answer!

> You will notice a quicker effect by doing this, but the effect may not last as long.

Because the AUC remains fixed, right?

> This may just be a matter of symantics though, since the half-life of Klonopin is fairly long anyway (18h to 80h, depending on how your body pharmacokinetically handles the drug - ie. rate of absorption, distribution, metabolism and excretion).

My understanding is that the duration of action doesn't depend only on the half-life, but also on other factors such as volume of distribution. Still, clonazepam is a long-acting benzo (possibly the longest -- what do you think?) and even if you increase the rate of absorption, it's liable to be long-acting still.

> I know of people who are taking a quarter of a 0.5mg tablet daily for anxiety related to bipolar disorder, and this is enough for them.

0.125 mg? That's too weird. 1 mg is at typical daytime dose for me, 2 mg at bedtime; but for panic attacks, I need 2 mg of *Xanax* (and this is on an empty stomach) to get full relief. I knew that 0.5 wasn't that unusual, but when I hear of people taking 0.125 that just falls short of shocking.

> Benzodiazepine doses are very individualized

Isn't that the truth?!

> You want the drug to ease the anxiety; this does not mean that you necessarily have to "feel it", as in giving you a buzz, or in any way altering your perception. Ideally, a benzo should take the edge off without having you feel otherwise different.

Thank you -- this is what I was trying to say, but you said it much better.





Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Elizabeth thread:86777