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Re: high-dose Effexor - anyone? Cam W.

Posted by Elizabeth on December 13, 2001, at 20:24:00

In reply to Re: high-dose Effexor - anyone? Elizabeth, posted by Cam W. on December 13, 2001, at 15:45:49

> Elizabeth - I wonder if one can use dosages to determine when the noradrenergic effects of Effexor would kick in.

I was thinking more of the dopaminergic effects. (Like I said, *high* doses, meaning 300+ mg/day.)

But I wonder -- I guess I assumed that at least some research had been done to this effect, but I never went and looked for it.

> We especially see differences in CYP-2D6 polymorphism.

Is CYP-2D6 involved in any of the metabolic pathways of Effexor? I'm particularly interested since there's good reason to believe that I have this polymorphism.

> I think that this factor might have something to do with the protracted withdrawl that some people experience (ie. those with naturally higher levels of CYP-2D6 metabolize the drug faster, thus setting themselves up for the withdrawl syndrome).

That might explain why I never experienced any kind of withdrawal from ADs other than MAOIs.





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