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Re: high-dose Effexor - anyone? Elizabeth

Posted by Cam W. on December 13, 2001, at 15:45:49

In reply to Re: high-dose Effexor - anyone?, posted by Elizabeth on December 13, 2001, at 15:19:45

Elizabeth - I wonder if one can use dosages to determine when the noradrenergic effects of Effexor would kick in. Everyone will have different complements of each of the receptors, as well as different rates of metabolism. We especially see differences in CYP-2D6 polymorphism. I think that this factor might have something to do with the protracted withdrawl that some people experience (ie. those with naturally higher levels of CYP-2D6 metabolize the drug faster, thus setting themselves up for the withdrawl syndrome). Perhaps this, as well as Effexor-induced changes in certain receptor concentrations, could make the withdrawl syndrome hell for some people).

I have wondered for a while if blood levels may give a more accurate indication of noradrenegic response (I doubt it, though). Phenotyping, when available, may give a better indication. I know that I really didn't respond until I was over 150mg of Effexor. Since I didn't respond to Paxil or Zoloft, even though I increased the dose to 60mg and 200mg, respectively - and did respond (at one time) to Wellbutrin - I think that the noradrenergic effects may have kicked in at 150mg to 225mg (although Paxil does have a fairly significant noradrenergic reuptake blocking effect - at least in vitro - I did not benefit from it, except for sleeping 10 hours a day). - Cam




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poster:Cam W. thread:86308