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Re: high-dose Effexor - anyone? angel1

Posted by Elizabeth on December 9, 2001, at 20:39:31

In reply to Re: high-dose Effexor - anyone?, posted by angel1 on December 9, 2001, at 6:51:30

> I'm sorry this is not about Effexor, but I thought
> you were on desipramine. What happen to that?

Desipramine did not work any better than Parnate had -- it helped, but not enough. I'm looking for something (and it may end up being a combination of somethings) that will help with the anhedonia and anergia that desipramine and Parnate didn't help with -- even though I wasn't all-out depressed, I still didn't have much interest in life or derive much enjoyment from things that I used to enjoy. This made it hard to function even though my mood was improved. Buprenorphine does help with the residual symptoms, but it's difficult to use (in various ways) and has a lot of side effects.

> Also, if you don't mind, what is your diagnosis?

"Major depressive disorder, recurrent, with melancholic features," in partial remission. Why?

> Actually, I am on effexor 150mg xr for about six
> weeks, total time on effexor nine weeks. It has
> definitely helped me, but I feel there is still room for improvement and will ask my doc if I can increase to 225mgxr. From what I've read and understand as you go to higher doses with this med it targets more or different neurotransmitters. Do you know if that is correct?

Yes, it is; Effexor and Remeron both have different effects that kick in at different doses. That's why I want to try to get above 300 mg/day. I'd say 75 is minimal, 150 is low, 225 is moderate, and 300+ is high. I've heard of people going much higher than 300, but I hope I won't need to.

-elizabeth


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poster:Elizabeth thread:86308
URL: http://www.dr-bob.org/babble/20011202/msgs/86404.html