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Re: atrophy of hippocampus jazzdog

Posted by manowar on December 4, 2001, at 13:00:59

In reply to Re: atrophy of hippocampus manowar, posted by jazzdog on December 3, 2001, at 22:48:48

> > > Tianeptine (Stablon-- a French antidepressant) has been shown to restore the hippocampus.
> >
> > Yes, I read the abstract on that study. Tianeptine is a Serotonin reuptake enhancer. From what I remember about the study, researchers only tried that particular drug in the research. They theorize that any good antidepressant would work to restore the hippocampus.
> Seratonin reuptake enhancer? Not inhibitor? I'd be interested in knowing more. I didn't realize such drugs existed.
> - Jane

Hi Jane,
Yea, it has the opposite effect on serotonin than the SSRIs do. It enhances the reuptake of serotonin while the SSRIs inhibit the reuptake of serotonin.

It's a French AD that can be obtained over the Internet. The literature that I have read on the drug has been all good, but of course IAS, the company that sells the drug, puts it out. The posts that I've read here haven't been too favorable. I don't think the drug is such a big deal that IAS claims it to be.

I found the study regarding tianeptine, here's the link--

Fascinating claim--
Tianeptine is supposed to have a novel effect on the hippocampus, and help overall cognitive improvement via neuronal regeneration. Fluoxetine and desipramine were also studied and did not have the same effect.

I do have a question for anyone out there. I have read that the monoamines serotonin and dopamine tend to counterbalance each other. In other words, when taking a SSRI serotonin levels are raised which decreases the levels of dopamine and NE. Any truth to this theory?




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