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Re: got a zanaflex prescription; wish me luck SLS

Posted by JohnX2 on November 30, 2001, at 23:04:34

In reply to Re: got a zanaflex prescription; wish me luck JohnX2, posted by SLS on November 30, 2001, at 19:42:59

Oops forgot to answer one of your questions,
the zanaflex is being prescribed for myofacial
pain. My pdoc says he can't understand my
pain and it needs to be looked at by a neurologist.
The neurologist said that I have already tried
everything in the book besides anti-spasmodics
and that is when he suggested zanaflex. I was
already interested in the possibility of an a2
agonist, so I was hip to the idea.

Another med I could try is baclofen (a gabaergic anti-spasmodic).
Baclofen has been shown to have anti-addictive/tolerance
properties like the nmda antagonists.

I also think Acamprosate (a combined gaba agonist/
nmda antagonist) or memantine (nmda antagonist)
may help. Acamprosate + memantine may be a very
potent combo. Supposedly great for TD.

Anyways, I'm also scheduled to get an MRI, but
the doc doesn't think it will show much.


> Hi John.
> > I've seen many references to Clonodine (Catapres)
> > being used for benzo withdrawl. I think this is
> > fairly common. I haven't seen much about Zanaflex.
> I was just becoming interested in tizanidine. I've already broached the subject of using clonidine with my doctor. He knows my feelings regarding my reactions to idazoxan and mirtazepine.
> I saw some stuff indicating that tizanidine might be as effective as clonidine in mitigating opioid withdrawal symptoms, but without the hypotensive side effects. I am looking forward to see you do well with it. Another drug that I would like to see brought to market is flesinoxan. Like buspirone, it is a 5-HT1a agonist. However, unlike buspirone (and ipsapirone), I don't think it has any metabolites that antagonize NE alpha-2 receptors. Woo hoo!
> I don't seem to be able to read or write in volume lately, so I apologize for not replying to some of your other posts. Besides, I would have to do quite a bit of remedial reading just to understand it all! So many interactions between circuits! I'm afraid I might blow the few I have left should I decide to try. :-) I am grateful that someone here is so strong at understanding neural circuitry and integrating it with the chemistry of neurotransmission.
> Is the Zanaflex being prescribed for myofacial pain? Is it expensive?
> By the way, how do you respond to Neurontin?
> - Scott




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