Posted by Sunnely on November 19, 2001, at 22:35:29
In reply to Does Wellbutrin inhibit cyp450-2d6, posted by JohnX2 on November 19, 2001, at 13:15:15
Yes. The primary concern will be the common practice of combining antidepressants in particular, Wellbutrin with a tricyclic antidepressant (TCA) such as nortriptyline, imipramine, and desipramine. This could lead to dramatic increase in TCA blood level, in turn leading to TCA toxicity such as lethargy/agitation, confusion, delirium (central anticholinergic toxicity), and even cardiac toxicity.
You should be aware that Wellbutrin SR and Zyban have exactly similar pharmacokinetic properties.
>
> Does wellbutrin inhibit the liver enzyme cyp-450 2d6?
> I've seen references that go both ways.
>
> thanks for any feedback,
> john
poster:Sunnely
thread:84667
URL: http://www.dr-bob.org/babble/20011113/msgs/84728.html