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Re: Starting on Topomax for Migraines. Advice anyone? Mitch

Posted by JohnX2 on November 14, 2001, at 3:06:46

In reply to Re: Starting on Topomax for Migraines. Advice anyone? JohnX2, posted by Mitch on November 13, 2001, at 23:35:31

> > It recommended buspar as one anti-dote, another
> > is a 5ht-2a antagonist. It suggested Serzone (which
> > worked great for me) or possibly Remeron (not quite
> > great). Didn't mention atypical anti-psychotics, but
> > I believe that a dabble of zyprexa et. al may do the
> > trick to.
> Well, can't do Remeron or Buspar due to the alpha-2 antagonist induced irritability (more "dirty" meds hitting receptors like a pin-ball game). If I went back on Serzone I would have to put up with some itching and difficulties seeing/reading, plus it is not very "liver-friendly", either.

I concur about the Remeron and Buspar a2 antagonism.
Neither helped as much as I would have liked.
The a2 antagonism increases the noradrenaline
conductice in that stress center that connects
to the serotonin path. So I think it counteracts
the 5ht-1a agonist in buspar and/or 5ht-2 antagonism
in Remeron.

I've always wondered if buspar would have been
a better anxiolytic w/o the alpha-2 side effect.
It incidently probably helped sales as people
discovered at the high dose of 60 mg it had some
antidepressant effect likely due to this.

PS. What is your current med cocktail?
Is it mainly Zoloft? I it would be novel to meet
someone on pbabble who was humming along on
1 ssri med. ;)





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